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KMID : 1123920180320010024
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Korean Journal of Oriental Physiology and Pathology
2018 Volume.32 No. 1 p.24 ~ p.29
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Effects of Torilis Fructus Extract on the Relaxation of Corpus Cavernosum
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Kim Ho-Hyun
Ahn Sang-Hyun
Park Sun-Young
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Abstract
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In order to define the effect of Torilis Fructus(TF) extract which has been used for the treatment of erectile dysfunction, experiments were carried out by organ bath study, histochemical and immunohistochemical methods. First, in the organ bath study, when TF extract was administered to the maxillary contracted corpus cavernosum by PE (10-6 M), there was a significant relaxation effect on corpus cavernosum at concentration of 1, 3 ㎎/㎖. Compared with the absence of L-NNA pretreatmen, pretreatment of L-NNA was inhibited the relaxation effect of penile corpus cavernosum. In the immunohistochemical study, the eNOS positive reaction was significantly increased, and the PDE5 positive reaction was significantly decreased due to the administration of TF extract. Therefore, it show that the TF enhances the production of eNOS and NO, inhibits PDE5 which blocks the action of increased cGMP, relaxes the corpus cavernosum. So TF relaxes the corpus cavernosum and it can be used as a safer erectile dysfunction treatment.
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KEYWORD
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Torilis Fructus(TF), Corpus cavernosum, Nitric oxide(NO), Endothelial nitric oxide synthases(eNOS), Phosphodiesterase5(PDE5)
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